Dr. Feargal J. Ryan
Academic qualifications:
- BSc. Microbiology (University College Cork, Microbiology;2011)
- MSc Bioinformatics & Systems Biology (University College Cork, Bioinformatics; 2012)
- PhD. ‘The mucosal microbiome in Inflammatory Bowel Disease’ (University College Cork, 2016).
Current appointments:
- Emerging leadership fellow, National Health and Medical Research Council (NHMRC), Australia
- Group leader and Level C academic – Flinders University, South Australia
- Vice-President, Australian Bioinformatics & Computational Biology Society (ABACBS)
Over the last decade I have gained extensive expertise inapplying bioinformatics and systems biology to understand human health and disease. I have co-authored >30 peer reviewed articles which have received >5,000 citations including top journals such as Science, Gut, and Cell Host & Microbe. Additionally I have been an investigator on over AUD $2M of research funding from multiple public and private sources including governmental agencies, charities and pharmaceutical companies.
For more information please see my Google scholar or ORCID profiles, or publication list below.
Publications list
| British Journal of Cancer – Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer |
| Science – Engineered bacteria detect tumor DNA |
| International Journal of Molecular Sciences – Selective transcription factor blockade reduces human retinal endothelial cell expression of intercellular adhesion molecule-1 and leukocyte binding |
| Cell Reports Medicine – A systems immunology study comparing innate and adaptive immune responses in adults to COVID-19 mRNA and adenovirus vectored vaccines |
| Communications Biology – Interpersonal variability of the human gut virome confounds disease signal detection in IBD |
| Cancer Research – Uncovering a novel role of peroxisomal β-oxidation in advanced, treatment-resistant prostate cancer |
| Vaccine – Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice |
| BMC medicine – Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection |
| STAR protocols – Protocol to assess the impact of early-life antibiotic exposure on murine longevity |
| Translational Vision Science & Technology – Transcriptomic responses of human retinal vascular endothelial cells to inflammatory cytokines |
| STAR protocols – Protocol to colonize gnotobiotic mice in early life and assess the impact on early life immune programming |
| Gut – Ranking microbiome variance in inflammatory bowel disease: a large longitudinal intercontinental study |
| Applied and environmental microbiology – A postbiotic consisting of heat-treated lactobacilli has a bifidogenic effect in pure culture and in human fermented fecal communities |
| Frontiers in immunology – Zika virus infection of human iris pigment epithelial cells |
| Cell Reports – The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life |
| Cell Reports Medicine – The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota |
| Nature communications – Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease |
| BMC biology – Autochthonous faecal viral transfer (FVT) impacts the murine microbiome after antibiotic perturbation |
| Microbiome – Choice of assembly software has a critical impact on virome characterisation |
| Microbiome – Short-term consumption of a high-fat diet increases host susceptibility to Listeria monocytogenes infection |
| Behavioural Brain Research – Differential gene expression in the mesocorticolimbic system of innately high-and low-impulsive rats |
| Cell host & microbe – The human gut virome is highly diverse, stable, and individual specific |
| Biology direct – Application of machine learning techniques for creating urban microbial fingerprints |
| ACS chemical neuroscience – Host microbiota regulates central nervous system serotonin receptor 2C editing in rodents |
| Msystems – Changes in the composition of the gut microbiota and the blood transcriptome in preterm infants at less than 29 weeks gestation diagnosed with bronchopulmonary dysplasia |
| Cell host & microbe – Whole-virome analysis sheds light on viral dark matter in inflammatory bowel disease |
| Cell host & microbe – Biology and taxonomy of crAss-like bacteriophages, the most abundant virus in the human gut |
| Microbiome – Reproducible protocols for metagenomic analysis of human faecal phageomes |
| PeerJ – Viromes of one year old infants reveal the impact of birth mode on microbiome diversity |
| Elife – Social interaction-induced activation of RNA splicing in the amygdala of microbiome-deficient mice |
| Microbiome – Long-term colonisation with donor bacteriophages following successful faecal microbial transplantation |
| Gut – Tumour-associated and non-tumour-associated microbiota in colorectal cancer |
| Translational psychiatry – Regulation of prefrontal cortex myelination by the microbiota |
| Brain, behavior, and immunity – Microbes & neurodevelopment–Absence of microbiota during early life increases activity-related transcriptional pathways in the amygdala |
| BMC bioinformatics – SPINGO: a rapid species-classifier for microbial amplicon sequences |
| F1000Research – Metatranscriptomics of colonic biopsies in inflammatory bowel disease |
FJR Bioinformatics 